Data Analysis of Genetic Variability in Alzheimer's Affected Brains


  • AKANKSHA TIBREWALA Aspiring Scientists' Summer Internship Program Intern
  • Aman Ullah Aspiring Scientists' Summer Internship Program Mentor



Data Analysis of Genetic Variability in Alzheimer's Affected Brains.AKANKSHA TIBREWALA and Aman Ullah, Department of School of Systems Biology and Department of Neuroscience, George Mason University.Alzheimer's disease (AD) has been widely recognized as the most common cause of dementia. Alzheimer's disease is a terminal neurological disorder that primarily affects the elderly and causes gradual memory loss and neurodegeneration. The National Institute on Aging-Association Alzheimer's (NIA-AA) analyzed and illustrated Alzheimer's disease (AD) as cognitive damage in 2011. AD steadily erodes a person's ability to learn, think, and communicate. According to Alzheimer's Disease International (ADI), over 50 million individuals worldwide were living with AD in 2019, and with approximately 10 million new cases every year, this figure is expected to rise to 82 million by 2030 and 152 million by 2050. There are two forms of Alzheimer's disease: early-onset Alzheimer's disease and late-onset Alzheimer's disease (LOAD). AD manifests itself as early-onset Alzheimer's disease between the ages of 30 and 60. This is a rarer form of Alzheimer's disease, affecting only 10% of all AD patients. Amyloid precursor proteins (APP) on chromosome 21, Presenilin (PSEN 1) on chromosome 14, and PSEN 2 on chromosome 1 are markers for early-onset AD. Late-onset Alzheimer's disease is more common and begins around the age of 60. No one gene causes LOAD, however, the presence of Apolipoprotein E (APOE) on chromosome 19 raises the risk. We will be studying gene expression data from 22 Alzheimer's patients and 9 controls. We will study the differences and similarities between the various severities of this condition, as 7 of the 22 participants have incipient Alzheimer's disease, 8 have intermediate Alzheimer's disease, and 7 have severe Alzheimer's disease. We will be able to correctly evaluate the data using principal component analysis (PCA).





College of Science: School of Systems Biology